体内和体外动物研究对阴茎勃起的triles terrestris和cornus officinalis的混合物的影响。
摘要来源:
j j sex med。 2012年10月; 9(10):2544-51。 EPUB 2012年8月20日。PMID: 22906304
摘要作者:Sung Chul Kam,Jung Mo do,Jae Hwi Choi,Byeong Tak Jeon,Gu Seob Roh,Gu Seob Roh,Jae Seog Hyun
文章隶属关系:泌尿外科,Gyeongsang国立大学医学院,Jinju,Jinju,Jinju,Korea。 class="sub_abstract_label">INTRODUCTION: Herbal preparations have long been used as folk remedies for erectile dysfunction (ED).
AIM: This study examined the effects of Tribulus terrestris and Cornus officinalis extracts on relaxation of the smooth muscle of the corpus海绵体(CC),其AC机制tion, and the effects of oral administration of a mixture of the herbal extracts on penile erection.
METHODS: The relaxation effects and the mechanisms of action of T. terrestris extract, C. officinalis extract, and the mixture of both extracts on the rabbit CC were investigated in an organ bath.为了评估器官浴中显示的CC的弛豫反应是否发生在体内,口服给药后在大鼠中计算了孔内压力(ICP)一个月。 Additionally, adenosine 3,5-cyclic monophosphate (cAMP) and guanosine 3, 5-cyclic monophosphate (cGMP) in the CC were measured using immunoassay.
MAIN OUTCOME MEASURES: Smooth muscle relaxation was expressed as the percent decrease in precontraction induced by苯肾上腺素。口服两种提取物的混合物1个月后,在大鼠中评估了ICP,CGMP和CA的变化变化根据两种提取物的混合物的浓度来测量MP浓度。
结果: t。陆甲菌提取物,C。officinalis提取物以及两种提取物的混合物均显示CC的浓度依赖性弛豫效应。在内皮筛化的组和N(g) - 硝基-L-精氨酸甲基酯预处理组中,T。tresteris提取物都抑制了松弛。口服提取物混合物一个月后测得的ICP高于对照组中测量的ICP,并且在混合组中观察到cAMP的显着增加。
结论: t。 terrestris提取物和C. officinalis提取物在器官浴中表现出浓度依赖性松弛。在提取物混合物的体内研究中,ICP和CAMP显着增强。因此,T。tresteris提取物和C. officinalis提取物的混合物可能会改善勃起功能。