lett Appl Microbiol。 2009年11月; 49(5):551-5。 EPUB 2009年7月24日。PMID: 19709367“ Valentini, F Santori
Article Affiliation:S F Bodini
Abstract:AIMS: The goal of this work was to investigate the influence of DMSO, garlic extract and p-coumaric acid on bacterial quorum sensing (QS).
方法和结果: QS报告基菌株的QS响应减少大肠杆菌psb401和psb536,tumefaciens ntl4,Chromoba,Chromoba,Chromoba根据生长抑制作用,对紫cer虫5999和WT 494,假单胞菌putida isof/gfp和环境假单胞菌杂草进行了量化。 DMSO即使在接近致命的浓度下也对所测试的菌株没有明显的特异性影响。大蒜提取物拮抗QS受体LuxR,Ahyr和Trar的活性,但在较高浓度下具有毒性。 P-coumaric acid fully inhibited QS responses of 5999, NTL4 and P. chlororaphis, with no influence on cell viability.
CONCLUSIONS: The quorum sensing inhibition activity of garlic was extended to novel receptors, and p-coumaric acid was found to possess previously undescribed QS拮抗剂性能。
研究的重要性和影响: 结果表明p-豆酸可能充当QS抑制剂。需要进一步的研究来了解其在QS调节中的作用对物结构相关的化合物。