Taxifolin Shows Anticataractogenesis and Attenuates Diabetic Retinopathy in STZ-Diabetic RatsSuppression of Aldose Reductase, Oxidative Stress, and MAPK Signaling Pathway.
Abstract Source:Endocr Metab Immune Disord Drug Targets. 2020; 20（4）：599-608。 PMID： 31656158“> 31656158
fei liu
摘要：
背景： 由于眼睛与糖尿病相关并发症（如糖尿病性视网膜病）和cantaract的糖尿病相关并发症的发生率增加，需要新的治疗剂，需要新的治疗剂。由于多酚化合物在糖尿病和相关并发症中享有的优点，我们假设出租车蛋白（TXF）是一种多酚黄酮醇，可以在糖尿病诱导的大鼠中表现出抗肉毒性和抗癌作用。abstract_label">METHODS: TXF at a dose of 10, 25, and 50 mg/kg was given by oral route to STZ mediated diabetic rats for a time period of 10 weeks. The opacity of lens was studied after every 7 days of treatment till 10 weeks; evaluation of the severity of cataract and changes in the histology of lens as well as retina was done. Tissue homogenates of lens isolated after the评估了研究的结尾，以下评估了氧化应激的标记，醛糖还原酶的水平，p38mapk，vegf和erk1/2。改善了氧化应激的状态，并抑制了p38mapk，VEGF和ERK1/2的水平，这也改善了糖尿病大鼠的透镜不透明度。对VEGF，ERK1/2，p38mapk和醛糖还原酶的影响。
结论： 研究证实，TXF证实了TXF是一种潜在的候选候选症状，显示了针对糖尿病诱导的视网膜症状和cat ract的保护作用。