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Abstract Title:Effects of naringin on physical fatigue and serum MMP-9 concentration in female大鼠
摘要来源:
Pharm Biol。 2017年12月; 55(1):423-427。 PMID: 27937032“> 27937032 Shamsizadeh,Mohammad Moemenzadeh,Morteza Amirteimouri,Mohammad Elshiekh,Mohammad Allahtavakoli
文章隶属关系:Mohammad Zamanian
摘要:
基质金属蛋白酶-9(MMP-9)的物理疲劳和激活。 NARINGIN(NAR)是一种具有抗氧化活性并抑制MMP-9表达的生物黄酮。
对象IVE: The present study evaluates the anti-fatigue activity of Nar on physical fatigue and serum MMP-9 concentration in rats.
MATERIALS AND METHODS: Fifty female Wistar rats were randomly divided into five groups (n = 10);对照组,车辆组和三个NAR治疗组。 NAR治疗组接受了不同剂量的NAR(40、80和160 mg/kg/day)30天。 30天,在详尽的游泳测试后立即牺牲了大鼠。测量血清MMP-9浓度和与疲劳有关的几个生化参数。
结果: NAR-80组中详尽的游泳时间显着增加了1.78-,1.78-,1.78-,1.53-,1.53-,1.5-,1.5-和1.3--1的nar,nar nar nar nar,nar nar,3-nar,nar nar,nar-nar nar,nar-nar-nar-nar-nar-nar-nar-nar-nar-nar-nar-nar-nar-nar-04。 分别。此外,与对照组相比,NAR-160组中详尽的游泳时间显着增加了1.36倍。 na与车辆和对照组相比,R-80将LDH活性显着降低了60.45%和57.47%。此外,与对照组相比,NAR-80和NAR-160分别增加了血糖水平19.56%和18.38%。 Nar-80 and Nar-160 significantly decreased serum MMP-9 concentration by 61.57% and 83.39% compared with the control group, respectively.
CONCLUSION: Based on our data, Nar has anti-fatigue effects which may be attributed to its property in modulating energy metabolism and减少血清MMP-9浓度。因此,NAR可能是治疗身体疲劳的有前途的药物。