抗氧化剂（巴塞尔）。 2019年12月6日； 8（12）。 EPUB 2019 12月6日。PMID： 318177734 31817734 Damico，Alessio Filippo Peritore，Marika Cordaro，Enrico Gugliandolo，Rosalia Crupi，Daniela Impellizzeri，Salvatore Cuzzocrea，Rosanna di Paola
文章隶属关系： Roberta fusco fusco
方法： 这项研究的目的是研究融化蛋白和粉状酸在比率模型中的叶酸酸性效果。 Sprague-Dawley male rats were injected with 1 mg/kg of reserpine for three consecutive days and later administered with melatonin, folic acid, or both for twenty-one days.
RESULTS: Administration of reserpine led to a significant decrease in the nociceptive threshold as well as a significant增加类似抑郁症的症状。这些行为变化伴随着氧化和亚硝化应激的增加。脂质过氧化显着增加，以及亚硝基酪氨酸和PARP表达，而超氧化物歧化酶，非蛋白硫醇和过氧化氢蛋白酶的表达显着降低。 endogenously produced oxidants species are responsible for mast cell infiltration, increased expression pro-inflammatory mediators, and microglia activation.
CONCLUSION: Melatonin plus acid folic administration is able to ameliorate the behavioral defects, oxidative and nitrosative stress, mast cell浸润，炎症介质的过表达和小胶质细胞激活与它们的疗效相比，其有效性更大。