eur Rev Med Pharmacol Sci。 2019年2月; 23（4）：1786-1788。 PMID： 30840304“> 30840304
atbract abracsive offort（s） lleshi，r taibi 文章隶属关系：u tirelli
摘要：
objective： 纤维肌痛是一种非常复杂的症状学。尽管普遍的剧烈疼痛被认为是这种疾病的基本症状，但许多其他相关症状，尤其是非调味性睡眠，慢性疲劳，焦虑和抑郁症状，在TH的残疾特征程度中也起着相关的作用疾病。臭氧疗法用于治疗多种疾病，似乎在治疗许多慢性疾病中特别有用，被认为是通过施加轻度，短暂和受控的氧化应激来起作用，从而促进抗氧化剂系统的上调和免疫系统的调节。 According to these mechanisms of action, it was hypothesized that ozone therapy could be useful in fibromyalgia management, where the employed therapies are very often ineffective.
PATIENTS AND METHODS: Sixty-five patients with fibromyalgia, according to the definition of the American College of Rheumatology (Arthritis从2016年2月至2018年10月，Rheum 1990; 33：160-172）在Mede诊所（意大利Pordenone，意大利）接受治疗。年龄范围从30至72岁不等，从纤维肌痛诊断的时间为0.5至33岁。治疗是由AutoHemotr进行的ansfusion in 55 patients and by ozone rectal insufflations in 10 patients, according to SIOOT (Scientific Society of Oxygen Ozone Therapy) protocols, twice a week for one month and then twice a month as maintenance therapy.
RESULTS: We found a significative improvement (>50% of symptoms) in 45例患者（70％）。没有患者报告重要的副作用。 In conclusion, at our knowledge, this is the largest study of patients with fibromyalgia treated with ozone therapy reported in the literature and it demonstrates that the ozone therapy is an effective treatment for fibromyalgia patients without significant side effects.
CONCLUSIONS: At the moment, ozone therapy seems a treatment that, also because没有任何副作用，就可以向没有获得其他可用治疗结果的纤维肌痛患者提出ED作为补充/综合医学。