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Abstract Title:Tanshinone IIA ameliorates the development of dermal fibrosis in systemic sclerosis.
Abstract来源：
临床Exp Pharmacol Physiol。 2023 NOV 30。明li，Qiao li
文章隶属关系：ying jiang
摘要：
目标：
方法： 博莱霉素用于建立SSC鼠标模型。棕褐色治疗后，测量了皮肤厚度，I型胶原蛋白和羟基含量。 Primary fibroblasts were acquired from SSc patients and cultured in vitro, and the effects of TAN IIA on proliferation, apoptosis and the cell cycle of fibroblasts were detected.
RESULTS: In a bleomycin-induced SSc model, we discovered that TAN IIA significantly improved skin thickness和胶原蛋白沉积，证明了有效的抗纤维化作用。棕褐色IIA通过引起G2/M细胞周期停滞并促进凋亡，抑制从SSC患者衍生的皮肤成纤维细胞的增殖。此外，棕褐色IIA以剂量梯度依赖性方式下调了皮肤成纤维细胞中细胞外基质基因转录和胶原蛋白表达。此外，我们展示了棕褐色IIA如何减少t的激活he transforming growth factor-β(TGF-β)/Smad and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathways, which are important factors in SSc.
CONCLUSIONS: In summary, these data suggest that TAN IIA can reduce SSc-related通过调节TGF-β/SMAD和MAPK/ERK信号通路来调节皮肤纤维化。更重要的是，我们的结果表明，棕褐色IIA可以直接作用于SSC的皮肤成纤维细胞，因此抑制纤维化。