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Abstract Title:L-carnitine treatment attenuates renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction.
Abstract Source:
韩国J Intern Med。 2020年9月18日。EPUB2020 9月18日。PMID： 32942841 Ying Li, Jian Jin, Ji Zhe Jin, Long Ye Zhang, Mei Ying Xuan, Xue Mei Jin, Yu Ji Jiang, Hai Lan Zheng, Ying Shun Jin, Yong Jie Jin, Bum Soon Choi, Chul Woo Yang, Shang Guo Piao, Can Li
Article Affiliation:Hai Yan Zhao
Abstract:
背景/目标： 累积证据表明L-肉碱（LC）通过其抗氧化特性和维护线粒体的保存来防止多机器人损害。很少有信息发出LC对肾纤维化的影响。这项研究检查了LC治疗是否会在单侧输尿管障碍物（UUO）的大鼠模型和体外。通过组织病理学评估LC对由UUO引起的肾脏损伤的影响，并分析基因表达，氧化应激，线粒体功能，程序性细胞死亡和磷脂酰肌醇3-激酶（PI3K）/ AKT/ AKT/ FORKHEAD/ FORKHEAD BOX BOX PONERE o 1A（FOXOO1A）信号。 In addition, H2O2-exposed human kidney cells (HK-2) were treated with LC.
Results: LC treatment inhibited expression of proinflammatory and profibrotic cytokines, and was followed by a significant attenuation of tubulointerstitial inflammation and fibrosis. UUO引起的氧化应激增加与线粒体有关通过PI3K/AKT/FOXO1A依赖性信号传导，Al功能障碍和过度凋亡和自噬，这通过LC的给药消除了。 In H2O2-exposed HK-2 cells, LC decreased intracellular production of reactive oxygen species, and suppressed expression of profibrotic cytokines and reduced the number of apoptotic cells.
Conclusions: LC protects against the progression of tubulointerstitial fibrosis in an obstructed肾脏。