摘要来源： 脂质健康。 2015; 14（1）：100。 EPUB 2015年9月3日。PMID： 263335572 Tian Yongnan Li BACKGROUND: A disruption of cholesterol homeostasis characterized by the physical-chemical imbalance of cholesterol solubility in bile often results in formation of cholesterol gallstones.我们较早的研究表明，姜黄素（1000 mg/kg）可以防止形成胆结石。已经证明了Curcumin吸收不良，而Piperine是一种生物利用度增强剂。 Nevertheless, whether curcumin combined with piperine could enhance the effect of curcumin in preventing gallstones is still awaited. METHOD: C57BL6 mice were fed on a lithogenic diet concomitant with curcumin at 500 or 1000 mg/kg and/or piperine at 20 mg/kg 4周。还记录了胆囊石的比例，还收集了血液，胆汁，胆囊，肝脏和小肠的样品。计算胆囊的体积和肝脏的重量，并通过生化方法分析血液和胆汁样品。通过实时PCR和Western印迹检测肠NPC1L1和SREBP2 mRNA和蛋白质表达。 结果： 与哌啶结合结合可以显着增强姜黄素的影响，从而使姜黄素的效应降低了，降低了胆汁素的发展。ion of blood lipids and cholesterol in bile, as well as decreasing the expression of NPC1L1 and SREBP2 in both mRNA and protein levels. CONCLUSION: Curcumin can prevent the formation of cholesterol gallstones induced by high fat diet in mice and SREBP2 and NPC1L1可以参与此过程。胡须可以增加姜黄素的生物利用度，从而增强姜黄素的作用。