红氨酸酸对乙醇诱导的胃炎的保护作用

Fatemeh Heidari

Background and purpose: Gastritis is one of the most current gastrointestinal disorders worldwide.饮酒是提供胃炎的主要因素之一。在许多植物中发现了红囊酸（RA），并且具有强大的抗氧化剂和抗炎作用。在这项研究中，保护性effect of RA was evaluated on the histopathological indices, antioxidant ability, and prostaglandin E2 (PGE2) secretion in male rats.

Experimental approach: Forty-two animals were divided into control, ethanol-induced gastritis, and RA groups, 6 each.保护组包括在50 mg（R-G50），100 mg（R-G100），150 mg（R-G150）和200 mg（R-G200）剂量的胃炎之前进行RA给药。禁食动物中1 ml纯乙醇的肿瘤诱导胃炎。胃炎1小时后，处死大鼠并去除胃组织。

发现/结果： 组织学评估表明，胃溃疡，脂肪细胞膨胀和超emia和超emia和超emia脂肪显着减弱。它还增加了粘膜层厚度和恢复的胃腺。此外，RA降低了丙二醛水平，超氧化物歧化酶，过氧化氢酶和谷物hione in the stomach tissue, and raised gastric PGE2 level.

Conclusion and implications: Our study demonstrated that rosmarinic acid has a notable effect on gastritis protection that could be due to increased antioxidant defense and PGE2 secretion, eventually maintenance of mucosal barrier integrity and gastric腺体。