licochalcone a通过调节UC.173。
摘要来源：
j Ethnopharmacol。 2023年8月14日; 318（pt b）：117044。 EPUB 2023 8月14日。PMID： 37586439 37586439 Song, Junyu Ke, Yanqiu Zheng, Gang Chen, Ning Li
Article Affiliation:Yajun Wang
Abstract:ETHNOPHARMACOLOGICAL RELEVANCE: Licorice can nourish Pi (spleen) and thereby strengthening the digestive system according to the theory of traditional Chinese medicine.甘草通常已在化合物处方中用于治疗肠道炎症性疾病。 Licochalcone A（LICO A）是LICORICE的特征分子之一。 T-UCR从超级保守的区域转录，是与肠EP续订相关的一类新的无编码RNAiThelial更新。
研究的目的： 这项研究旨在研究LICO A的效果和UC.173相关机制对肠道上皮上皮的机制对肠上皮上皮的RENEWAL。 IE-6和CACO-2细胞用于评估LICO A对IEC凋亡，增殖和迁移的影响。肠道类器官用于研究LICO的离体效应和促进肠道器官发育的机理。 C57BL/6J小鼠（正常和UC.173缺乏）用于检查LiCo A对肠粘膜更新的体内效应。
： sustall of 3 t-t-uc的表达， LICO A处理的IEC。 LICO A促进了增殖，并通过UC.173/Mir-195途径抑制了IEC的凋亡。肠道有机体的发展ds and the renewal of intestinal mucosa of mice subjected to the 48-h FAST were all promoted by the treatment of Lico A. Moreover, the growth arrest of uc.173-deficient intestinal organoids and the atrophy of intestinal mucosa in uc.173-deficient mice could be rescued by the Lico A administration.
CONCLUSION: Results in this paper suggest that targeting T-UCRs may be the novel therapeutic approach for the promotion of epithelial regeneration, and through stimulating the regeneration of intestinal mucosa, Lico A may become a new therapeutic agent for the maintenance of intestinal epithelial integrity.