黑胡椒含有包括5-α还原酶抑制活性的佛中的化合物，可防止睾丸激素转化为二氢睾丸激素，这是雄激素性脱发的危险因素

睾丸激素5Alpha-reductase抑制性活性活性成分。

biol Pharm Bull。 2007年12月; 30（12）：2402-5。 pmid： 18057734

Noriko Hirata，Masashi Tokunaga，Shunsuke Naruto，Munekazu Iinuma，Hideaki Matsuda

Excerpt: "Previously we reported that Piper nigrum leaf extract showed a potent stimulation effect on melanogenesis and that (-)-cubebin (1) and (-)-3,4-dimethoxy-3,4-desmethylenedioxycubebin (2) were isolated as active constituents. As a part of our continuous studies on Piper species for the development of cosmetic hair-care睾丸激素5阿尔帕氏二重还原酶抑制性乙醇提取物的抑制作用，从六个吹笛物种的几个部分中获得，即Piper nigrum，P。p. betle，P。betle，P。kadsura，P. longum和P. cubeba它们，斑岩叶疟原虫的提取物，尼格鲁姆果实和cubeba果实表现出有效的抑制活性。 Activity-guided fractionation of P. nigrum leaf extract led to the isolation of 1 and 2. Fruits of P. cubeba contain 1 as a major lignan, thus inhibitory activity of the fruit may be attributable to 1. As a result of further assay on other known constituents of the cited Piper species, it was found that piperine, a major alkaloid amide of P. nigrum fruit, showed potent inhibitory activity, thus a part of the斑岩假单疟原虫的抑制活性可能取决于尖白。首次发现了5阿尔法还原酶抑制活性的5alpha-还原酶抑制活性。此外，斑岩叶叶叶提取物在睾丸激素敏感的雄性C57Black/6CrSLC菌株小鼠中使用头发再生测定法显示了体内抗雄激素活性。”