Click here to read the complete article.
Abstract Title:Salvianolic Acid B Reduces Oxidative Stress to Promote Hair-Growth in Mice, Human Hair Follicles and皮肤乳头细胞。
摘要来源：
临床cosmet研究皮肤病。 2024; 17：791-804。 EPUB 2024 4月8日。PMID： 38616888888888888888888 Zhou，Mengyi Wu，Yuting Zhang，Jui-Ming Lin，Yan Huang，Yuou Sha，Jiayi Wang，Sirapath Peter Kong，Jinran Lin，Qingmei Liu，Wenyu Wu
文章附属：traidit thianthanthanythanythanythanythanyakij
class =“ sub_abstract_label”>背景： 现有研究将氧化应激和炎症连接到脱发。 salvianolic Acid B（SAB）以其抗氧化，抗炎和其他有益药理而闻名properties.
OBJECTIVE: To assess the efficacy of SAB in modulating hair growth.
METHODS: In vivo experiments were conducted using C57BL/6 mice to evaluate the effects of SAB在头发和皮肤参数上。该研究涉及人毛囊（HFS）的体内分析，以进行头发长度和头发生长周期评估。在体外，用SAB培养人类皮肤乳头细胞（HDPC），并使用各种分析技术，包括实时细胞分析（RTCA），DCFH-DA分析，DCFH-DA分析，RNA-seq和KEGG PATH和结果： 小鼠的SAB治疗可显着改善头发生长和血管化，到第21天。到Catagen阶段。 SAB-treated hDPCs showed a notable decrease in the expression of oxidation-antioxidation-related genes and proteins, including reduced phosphorylation levels of ERK and p38.
CONCLUSION: The study indicates that SAB promotes hDPC proliferation and offers protection against oxidative压力，强调了其作为增强头发生长和治疗脱发的治疗剂的潜力。