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Abstract Title:Effects of honokiol combined with resveratrol on bacteria responsible for oral malodor and their生物膜。
摘要来源：
j口服微生物。 2024; 16（1）：2361402。 Epub 2024 Jun9。pmid： 38860120“> 38860120 Huang，Zhiwen OU，Zhibin Shen
文章隶属关系：Shiqian Zheng
摘要：
背景： 这项研究旨在研究Honokiol对honokiol对多余的Malodor的效果生物膜。
方法： 这项研究研究了针对PG和FN的药物MIC，FICI和动态杀菌性活动。药物对生物膜代谢活性，生物膜总量和生物膜微结构的影响分别通过CCK-8实验，半定量粘附实验和SEM确定。 The effects of drugs on biofilm genes, extracellular polysaccharides, proteins and DNA content were determined by qRT-PCR, phenol-sulfuric acid method, BCA method and Nano Drop one C, respectively.
RESULTS: The combination had synergistic antibacterial effect on Pg and fn。 1/2×MIC和1×MIC组合抑制了PG和FN生长的整个过程。结果表明，该组合有效地减少了生物膜代谢活性和总量，并破坏生物膜微结构。结果表明，该组合下调了基因表达PG和FN，降低了PG的细胞外多糖和DNA，并减少了Fn。
结论：This study showed that the combination had a synergistic antibacterial effect on Pg and Fn, reduced the biofilm extracellular matrix, inhibited biofilm formation, and downregulated the expression of genes related to biofilm formation.