α-硫酸对与年龄相关的听力损失的A/J小鼠的眼球保护作用。
摘要来源：
otol otol Neurotol。 2020 Jul; 41（6）：E648-E654。 PMID： 32282782“> 32282782 Bingxin Zhou，Yi Xie，Mengmeng Zhao，Ping Li，Peng Lu，Peng Lu，Tingyan Liu，Fengchan Han
文章隶属关系：Shanshan Huang
摘要：
方法： a/j小鼠幼崽在第7天未经培养的组，二二硫代硫化物，二二碱。（DMSO）组和α-硫酸+DMSO组。每隔一天，以50μg/g体重的剂量将α-脂肪酸以50μg/g体重的剂量给予小鼠。测试了时间课程听觉诱发的脑干反应（ABR）阈值。 OHC loss was counted and the densities of SGNs and the width of stria vasculariswere measured at 4 and 8 weeks of age.
RESULTS: Measurement of the ABR thresholds revealed that hearing loss in A/J mice was attenuated byα-lipoic acid at age from 3 to 8 weeks. Moreover, preservation effects of OHCs, SGNs, and stria vascularis by α-lipoic acid were observed in the cochleae of A/J mice at 4 and 8 weeks of age.
CONCLUSION: Hearing loss in A/J mice can be attenuated byα-lipoic acid. α-硫酸对A/J小鼠的触角作用可以通过在耳蜗中保存OHC，SGNS和Stria Vascularis来获得A/J小鼠。与GE有关的氧化损伤NE突变可能是预防AHL和治疗的潜在目标。