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Abstract Title:Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta-analysis of Randomized Controlled试验。
摘要来源：
Clin Cardiol。 2015年9月28日。epub 2015年9月28日。pmid： 26415519 Yu-Feng Zhang，清重Xia，Jia Qi，Jian-chang Chen
文章隶属关系：wei-long jiang
摘要：
background：backgack：
方法： 我们搜索了2015年6月的PubMed，Embase和Cochrane数据库，并包括7个随机对照试验，这些试验研究了对CHF患者心血管癌对CHF患者的影响。然后，我们对临床试验进行了荟萃分析，以确认补充维生素D对CHF患者是否有益。 The weighted mean difference (WMD) and 95% confidence interval (CI) were calculated using fixed- or random-effects models.
RESULTS: Our pooled results indicated that additional supplementation of vitamin D was not superior to conventional treatment in terms of left ventricular ejection fraction, N-terminal pro-B-type NATRIARITE肽，步行6分钟。此外，补充维生素D与肿瘤坏死因子-α水平的显着降低有关（WMD：-2.42 pg/ml，95％CI：-4.26to -0.57, P<0.05), C-reactive protein (WMD: -0.72 mg/L, 95% CI: -1.42 to -0.02, P<0.05), and parathyroid hormone (WMD: -13.44 pg/mL, 95% CI: -21.22 to -5.67, P<0.05).
CONCLUSIONS: Vitamin D supplementation may decrease serum levels of parathyroid hormone and inflammatory mediators in CHF patients, whereas it has no beneficial effects on improvement of left ventricular function and exercise tolerance.