可以将椭圆酸视为针对人类中H幽门相关胃疾病的有希望的抗菌剂

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在抗菌素耐药性中，针对幽门螺杆菌感染的廉价，基于饮食的治疗将引起人们的极大关注。进行了本研究以评估椭圆酸对临床葡萄菌株的体外作用，这些菌株对用于治疗的抗生素具有抗性，并观察到t之后的形态结构用椭黄酸进行布置。 The effectiveness of ellagic acid in eradicating H. pylori infection in a murine (C57BL/6) infection model, one of the standard inbred mouse lines often used for experimental infection, was also assessed.

Methods: A total of 55 strains were screened.使用琼脂稀释方法来确定分离株对化合物的敏感性。透射电子显微镜用于观察用椭圆酸治疗后的形态。通过组织学和PCR确定了幽门螺杆菌SS1感染的小鼠模型及其对胃粘膜损伤的影响。椭圆酸的MIC范围为5至30 mg/L，显示其体外的杀菌特性。椭圆酸也表现出抗H。幽门螺杆菌功效in eradication of this organism in an in vivo model, as well as restitution and repair of H. pylori-induced gastric mucosal damage.

Conclusions: The present study paves the way for the preventive and therapeutic use of ellagic acid against H. pylori infection and, thus, ellagic acid可以被认为是人类中针对幽门螺杆菌相关的胃杀伤型胃疾病的有希望的抗菌剂。