icariin通过抑制星形胶质细胞激活来减轻由出血性休克和复苏引起的焦虑样行为。
摘要来源：
phytomedicine。 2024 Jun; 128：155507。 EPUB 2024 3月19日。PMID： 38552430“> 38552430 Xiao，明明张，Zhi-fang Yu，Ji-Zhen Liu，Wei Zhang，Li-Min Zhang，Bao-Rui Xing，Ting-ting Zhou，Xiao-Ming Li，Xiao-Chun Zhao，Ping an
dongn-dong-dong-dong-dong-p> Prackrip-pr> Afffercation Appport class =“ sub_abstract_label”>背景： 杏仁核中星形胶质细胞的异常激活有助于出血性休克和复苏后的焦虑（HSR）。活化B细胞（NF-κB）相关的表观遗传重编程的核因子κ-光链增强体对于焦虑至关重要。衍生自伊卡林蛋白（ICA）的生物活性单体已成为移植以调节NF-κB信号传导和星形细胞激活。目的： 本研究旨在研究ICA对HSR焦虑症的影响及其对后HSR焦虑症的影响及其对动作的潜在方法。 我们首先通过出血和再输入模型诱导小鼠中的HSR，并使用化学遗传学有选择地抑制和活化的星形胶质细胞。然后，每天通过口服烤一次21天，通过口服烤一次ICA（40 mg/kg）。 Behavioral, electrophysiological, and pathological changes were assessed after HSR using the light-dark transition test, elevated plus maze, recording of local field potential (LFP), and immunofluorescence assays.
RESULTS: Exposure to HSR reduced the duration of the light chamber and attenuated open-arm条目。此外，HSR暴露提高了Theta振荡能力杏仁核和上调的NF-κBp65，H3K27AC和H3K4me3表达。相反，星形胶质细胞的化学抑制作用显着逆转了这些变化。 Chemogenetic inhibition in astrocytes was simulated by ICA, but chemogenetic activation of astrocytes blocked the neuroprotective effects of ICA.
CONCLUSION: ICA mitigated anxiety-like behaviors induced by HSR in mice via inhibiting astrocytic activation, which is possibly associated与NF-κB诱导的表观遗传重编程。