阿氏素蛋白针对多种人类疾病的治疗潜力：一种机械评论。
摘要来源：
植物医学。 2023年2月; 110：154647。 EPUB 2023 1月2日。PMID： 36628833 36628833 Zhihui Zheng, Lijun Chen
Article Affiliation:Guanming Wang
Abstract:BACKGROUND: Arctigenin (ATG), a dibenzyl butyrolactone lignan compound, is one of the major bioactive components from the medicinal plant Arctium拉帕。 ATG具有针对广泛的人类疾病的显着治疗潜力，例如癌症，免疫疾病和慢性病。已经深入研究了ATG生物学作用背后的分子机制。
目的： 本次评论旨在系统地总结the updated knowledge of the proteins and signaling pathways behind the curative property of ATG, and further analyze the potential connections between them.
METHOD: SciFinder, Pubmed, Web of Science and Cochrane Library databases were queried for publications reporting the therapeutic properties of ATG. "Arctigenin", "disease", "cancer", "inflammation", "organ damage", "infection", "toxicity" and "pharmacokinetics" were used as the searching titles.
RESULT: 625 publications were identified and 95 met the inclusion criteria and exclusion criteria. 42研究描述了与ATG处理有关的分子机制。几种蛋白质包括磷酸二酯酶亚型4D（PDE4D），雌激素受体（ER）β，蛋白质磷酸酶2a（PP2A），磷酸肌醇3-激酶（PI3K）和跨膜蛋白16A（TMEM16A）的磷酸肌醇3-激酶（PI3K）（TMEM16A）在不同的设置中针对不同的设置。经常described signaling pathways are TLR4/NF-κB, PI3K/AKT/mTOR, AMP-activated protein kinase (AMPK) and nuclear factor erythroid 2-related factor 2 (Nrf-2) signalings.
CONCLUSION: Inhibition of PI3K/AKT AMPK信号传导的途径和激活在ATG的治疗作用中起关键作用。 PI3K/AKT和AMPK信号传导与其他信号通路广泛联系，调节了各种生物学过程，例如抗炎，抗氧化应激，抗纤维化，抗纤维化，抗ER应激，抗史塔病和促凋亡，构成了ATG的治疗机制，这些机制构成了ATG的治疗机制。