Berteroin通过AMPK介导的肝脂质代谢和抑制脂肪细胞分化的调节来改善脂质的积累。
摘要来源：
life sci。 2021年6月1日：119668。 EPUB 2021 Jun1。pmid： 34087283 Lee
Article Affiliation:Yeon Ju Kim
Abstract:AIMS: Berteroin (5-methylthiopentyl isothiocyanate) is a naturally occurring sulforaphane analog containing a non-oxidized sulfur atom in cruciferous vegetables. The objectives of the present study were to determine the effects of berteroin on lipid metabolism in hepatocytes and adipocytes and to elucidate the mechanisms involved.
MAIN METHODS: The effect of berteroin on lipid metabolism were evaluated in liver X recePTORα激动剂使用MTT分析，蛋白质印迹，实时聚合酶链反应，油红O染色和甘油三酸酯测定法和甘油三酸酯测定法。
SIGNIFICANCE: Our results suggest berteroin-inhibited hepatic lipid accumulation and adipocyte differentiation might be mediated by AMPK激活和berteroin可能可用于预防，改善和治疗代谢疾病，包括肝脂肪变性。