甘氨酸作为针对丙型肝炎病毒的抗病毒剂。
摘要来源：
j transp med。 2011; 9：112。 EPUB 2011年7月18日。PMID： 21762538
摘要作者：Usman A Ashfaq，Muhammad S Masoud，Zafar Nawaz，Sheikh Riazuddin
文章隶属关系：分子医学分子，国家卓越分子生物学中心，旁遮普大学，旁遮普大学，旁遮普大学，巴基斯坦，帕基斯坦。 class =“ sub_abstract_label”>背景： 丙型肝炎病毒是慢性肝病的主要原因，可导致永久性肝脏损伤，肝细胞癌和死亡。目前使用Interferon Plus Ribavirin的治疗方法由于不利的副作用，例如贫血，抑郁症，疲劳和“流感状”症状。 Herbal plants have been used for centuries against different diseases including viral diseases and have become a major source of new compounds to treat bacterial and viral diseases.
MATERIAL: The present study was design to study the antiviral effect of Glycyrrhizin (GL) against HCV. For this purpose, HCV infected liver cells were treated with GL at non toxic doses and HCV titer was measured by Quantitative real time RT-PCR.
RESULTS AND DISCUSSION: Our results demonstrated that GL inhibit HCV titer in a dose dependent manner and resulted in 50% reduction of HCV at a concentration 14±2μg。与干扰素α进行了比较研究，以研究抗病毒化合物和干扰素α2A之间的协同作用（如果有）。我们的数据表明，与干扰素结合使用时，GL表现出协同作用。而且，这些通过用HCV 3A核质粒瞬时转染肝细胞来验证SULT。 The results proved that GL dose dependently inhibit the expression of HCV 3a core gene both at mRNA and protein levels while the GAPDH remained constant.
CONCLUSION: Our results suggest that GL inhibit HCV full length viral particles and HCV core gene expression or function in a dose dependent manner and had与干扰素的协同作用。将来，GL与干扰素一起将是治疗HCV感染的更好选择。