褪黑激素对大鼠的影响在暴露于亚洲剂量的除草剂剂量的妊娠第三阶段。
摘要来源:
acta asta Histochem。 2017年4月; 119(3):220-227。 EPUB 2017 2月13日。PMID: 28202179 28202179 Coelho Teixeira,AnísioFranciscoSoares,Franklin Magliano da Cunha,Valdemiro Amaro da Silva,Leucio Duarte Vieira Filho,ValéririaWanderley-Teixeira 文章附属: class =“ sub_abstract_label”>: 暴露于除草剂paraquat(pq)和综述(®)可能会导致细胞病变,因为在生殖系统中,不同生物系统中氧化应激水平的增加,即使在生殖系统中也会引起。生殖参数和肝由于它通过同时应用褪黑激素的预防。
方法: 3个月时的三十五岁雌性大鼠分为七组:三组暴露于Herbicides pq(50mg/kg)的亚属剂量(; (n = 5,g2,g3和g4);从怀孕的第一天到第七天,三组暴露于除草剂和10mg/kg褪黑激素(N = 5,G5,G6和G7)和对照组(n = 5,G1)的同时治疗。在怀孕的第七天,将大鼠麻醉并安乐死,然后进行剖腹手术,以去除其生殖组织和肝脏。 Body and ovary weights were taken and the number of implantation sites, corpora lutea, preimplantation losses, implantation rates were counted and histopathology of the implantation sites, morphometry of the surface and glandular epithelia of endometrium and hepatic oxidative stress were undertaken.
CONCLUSIONS: These results reveal that melatonin is a protective agent against具有除草剂的实验诱导的母体/胚胎毒性,并有利于生殖参数和肝的归一化。