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Abstract Title:Effect of high sugar intake on glucose transporter and weight regulating hormones in mice and人类。
抽象来源：
plos One。 2014; 9（7）：E101702。 EPUB 2014年7月10日。PMID： 25010715 25010715 Dhaese，Barbara Ernst，Martin Thurnheer，Bernd Schultes，Stephan c bischoff
文章隶属关系：yvonne ritze
摘要：
able_label“> abvisies： appocition： sugarpumption在最终的six中越来越多地逐渐脱颖而出。特别是摄入糖饮料的摄入似乎是肥胖发展的主要风险。因此，我们在饮食摄入量中比较了液体与固体高糖饮食inal uptake and metabolic parameters in mice and partly in humans.
METHODS: Five iso-caloric diets, enriched with liquid (in water 30% vol/vol) or solid (in diet 65% g/g) fructose or sucrose or a control diet were fed for eight weeks to C57bl/6老鼠。测量了糖，液体和热量摄入，小肠糖转运蛋白（GLUT2/5）和调节激素mRNA表达的重量以及肝脂肪的积累。 In obese versus lean humans that underwent either bariatric surgery or small bowel resection, we analyzed small intestinal GLUT2, GLUT5, and cholecystokinin expression.
RESULTS: In mice, the liquid high-sucrose diet caused an enhancement of total caloric intake compared to the solid高核饮食和对照饮食。此外，液体高核饮食增加了回肠中GLUT2，GLUT5和胆囊动蛋白表达的表达（P <0。001）。与对照组相比，在喂食液体高核或 - 果糖的小鼠中观察到肝脏甘油三酸酯的积累增强。 In obese, GLUT2 and GLUT5 mRNA expression was enhanced in comparison to lean individuals.
CONCLUSIONS: We show that the form of sugar intake (liquid versus solid) is presumably more important than the type of sugar, with regard to feeding behavior, intestinal sugar uptake and liver fat accumulation in mice.有趣的是，在肥胖个体中，与精益个体相比，肠道糖转运蛋白也发生了调节。