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Abstract Title:Supplementing Glycine and N-acetylcysteine (GlyNAC) in Aging HIV Patients Improves Oxidative应力，线粒体功能障碍，炎症，内皮功能障碍，胰岛素抵抗，遗传毒性，强度和认知
摘要来源：
生物医学。 2020年9月30日； 8（10）。 EPUB 2020 9月30日。PMID： 33007928 Suliburk, Charles G Minard, Raja Muthupillai, Shaji Chacko, Jean W Hsu, Farook Jahoor, Rajagopal V Sekhar
Article Affiliation:Premranjan Kumar
Abstract:Patients with HIV (PWH) develop geriatric comorbidities, including functional and cognitive decline at a younger age.但是，贡献机制尚不清楚，并且缺乏干预措施。我们hypothesized that deficiency of the antioxidant protein glutathione (GSH) contributes to multiple defects representing premature aging in PWH, and that these defects could be improved by supplementing the GSH precursors glycine and N-acetylcysteine (GlyNAC).We conducted an open label clinical trial where eight PWH and eight matched uninfected-controls were studied at baseline.在接受Glynac后，再次对PWH进行了12周的研究，并在停止Glynac后进行了8周。控件没有得到补充。结局措施包括红血细胞和肌肉GSH浓度，线粒体功能，线粒体和自噬，氧化应激，炎症，炎症，内皮功能，基因组损伤，胰岛素抵抗，葡萄糖产生，肌肉蛋白质蛋白的分解率，身体成分，功能和CognitiTion.PWH具有大量抑制作用。但是，停止Glynac后退后的福利。此公开标签试验发现PWH具有基于多个生物学和功能缺陷的过早衰老，并确定了认知和身体下降的新机械解释。补充甘草的营养补充可改善合并症，提示PWH的过早衰老，包括功能和认知能力下降，并保证进行额外的研究。