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Abstract Title:

Hypersensitivity reactions to human papillomavirus vaccine in Australian schoolgirls:回顾性队列研究。

摘要来源:

bmj。 2008年12月2日; 337:A2642。 EPUB 2008年12月2日。PMID: 19050332“> 19050332 吉姆·巴特(Jim Buttery),詹妮·罗伊尔(Jenny Royle),迈克尔·戈尔(Michael Gold),克里斯汀·齐格勒(Christine Ziegler),帕特里克·奎因(Patrick Quinn),桑贾·埃里亚(Sonja Elia),莎朗·乔(Sharon Choo)

文章隶属关系:

liew woei kang

摘要:

设计: 回顾性队列研究。

设置: 两个Tertiary Pediariary Pediariary Pediary eLlergy中心在Victoria和South Australia and Australia and Australia and atularter aterucation,paster,P> class="sub_abstract_label">PARTICIPANTS: 35 schoolgirls aged 12 to 18.9 years with suspected hypersensitivity reactions to the quadrivalent human papillomavirus vaccine.

MAIN OUTCOME MEASURES: Clinical review and skin prick and intradermal testing with the quadrivalent vaccine and subsequent challenge with the vaccine.

RESULTS: 35 schoolgirls with suspected hypersensitivity to the quadrivalent human papillomavirus vaccine were notified to the specialised immunisation services in 2007, after more than 380 000 doses had been在学校管理。在这35名女学生中,有25名同意进一步评估。 TW第一次剂量后,Enty三(92%)经历了反应。 13(52%)经历了荨麻疹或血管性多气,其中两个经历了过敏反应。 13个概括了皮疹,其中有血管性充血性。反应的中位时间为90分钟。十九(76%)使用四价疫苗进行了皮肤测试:所有疫苗都是皮肤刺测阴性的,一个是皮内测试阳性。随后,有18个(72%)受到四价疫苗的挑战,三分(12%)当选为接受二价疫苗。 17次挑战可容忍挑战,并报告了疫苗服用四个小时后的荨麻疹有限。 Only three of the 25 schoolgirls were found to have probable hypersensitivity to the quadrivalent vaccine.

CONCLUSION: True hypersensitivity to the quadrivalent human papillomavirus vaccine in Australian schoolgirls was uncommon and most tolerated subsequent剂量。

研究类型 : 人类研究
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