摘要来源： 脂质健康疾病。 2018年7月26日； 17（1）：173。 EPUB 2018年7月26日。PMID： 30049280“> 30049280 Liu, Mengye Li, Yingshu Liu, Fan Yang, Zuowei Pei Jingyi Xu BACKGROUND: Hypercholesterolemia is a well-established risk factor for cardiac damage, which can lead to cardiovascular diseases.许多研究表明，胸醌保护大鼠免受阿霉素诱导的心脏毒性和心脏损伤。这项研究的目的是研究可能的保护作用of thymoquinone against cardiac damage in apolipoprotein E knockout (ApoE) mice. METHODS: Eight-week-old male ApoEmice were randomly divided into three groups: control group fed a normal diet (ND group), a high cholesterol diet (HD group) or HD mixed with thymoquinone （HD+TQ组）。所有组均喂养不同的饮食持续8周。从下腔静脉获得血液样本，并在血清管中收集。然后将样品存储在-80°C直至使用。心脏组织的冠状切片固定在10％福尔马林中，然后嵌入石蜡中进行组织学评估。 The remainder of the heart tissues was snap-frozen in liquid nitrogen for mRNA or immunohistochemical analysis. RESULTS: The metabolic characteristics of total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-c), and high-sensitivity C-reactive蛋白质（HS-CRP）较低APOEHD+TQ小鼠比APOEHD小鼠。在APOEHD+TQ小鼠的心脏组织中，凝集素样氧化的低密度脂蛋白受体1（LOX-1）基因和蛋白质表达低于APOEHD小鼠的蛋白质。 Furthermore, the levels of macrophages and pro-inflammatory cytokines were lower in the cardiac tissues of ApoEHD + TQ mice than in those of ApoEHD mice. CONCLUSIONS: These results indicate that thymoquinone may provide a potential therapeutic target for cardiac damage caused by高胆固醇血症。