槲皮素降低了喂养富含蛋氨酸的饮食的大鼠血清同型半胱氨酸水平。
摘要来源:
营养。 2013年4月; 29(4):661-6。 EPUB 2013 2月12日。PMID: 23410631 23410631 Yang, Jianquan Wu, Lingling Pu, Changjiang Guo
Article Affiliation:Bin Mengp>Abstract:
OBJECTIVE: The aim of this study was to determine the effects of quercetin on homocysteine (Hcy) metabolism and hepatic antioxidant status in high甲硫氨酸(Met) - 喂老鼠。
方法: 大鼠被喂食6周的饮食:对照组为1.0%,MET,1.0%MET和0.1%槲皮素,1.0%MET和0.5%MET和0.5%quercetin quercetIn,1.0%quercet inde quercet and d Intured quercret and d Intured和2.5%和2.5%un和2.5%un和2.5%。血清HCY,Met,半胱氨酸,丝氨酸,牛磺酸,谷胱甘肽(GSH),槲皮素及其元分析了苯胺转氨酶(ALT)和天冬氨酸转氨酶(AST)的活性。 Hepatic malondialdehyde, GSH and carbonyls, and activity of superoxide dismutase and ferric-reducing antioxidant power also were measured.
RESULTS: Serum Hcy was increased significantly after Met treatment and decreased after quercetin supplementation.同时,血清牛磺酸增加,丝氨酸降低。 However, the content of GSH in serum and liver was decreased in the quercetin-supplemented groups and activities of serum ALT and AST were enhanced in the 1.0% Met and 2.5% quercetin-supplemented groups.
CONCLUSIONS: Quercetin is effective in decreasing serum Hcy level in high MET喂养的大鼠和可能的机制之一与HCY的转化增加有关。槲皮素可以在高进气水平上充当促氧化剂。