来自棕色海藻腹膜结节的富谷烷可改善载脂蛋白E缺陷小鼠的动脉粥样硬化

jiayu yin yin

Hyperlipidemia是动脉粥样硬化的主要原因。 Reverse cholesterol transport (RCT) is believed to attenuate hyperlipidemia and the progression of atherosclerosis. Although fucoidans are reported to have hypolipidemic effects, the underlying mechanisms are unclear. Furthermore, few reports have revealed the anti-atherosclerotic effects and the underlying mechanisms of fucoidans. This study was designed to investigate the anti-atherosclerotic effect and mechanisms来自海藻A. nodosum的fucoidan。我们的结果表明，岩藻依林甘油给药以剂量依赖性的方式以载脂蛋白E缺陷型（APOE）小鼠的身份以剂量依赖性方式改善动脉粥样硬化病变和脂质谱。在顶膜肝中，岩藻糖素治疗显着增加了清道夫受体B型1（SR-B1）的表达，过氧化物酶体增殖物激活受体（PPAR）α和β，肝X受体（LXR）α，ATP结合Cassette Transporter（ABC）A1和ABCG8;并明显降低了PPARγ和固醇调节元素结合蛋白（SREBP）1C的表达，但并非低密度脂蛋白受体，普罗蛋白转化蛋白转化酶枯草蛋白/Kexin 9型，胆固醇7alpha-Hydroxylase A1，LXRβ和ABCG1。在小瓶的小肠中，岩藻依氨木治疗显着降低了Niemann-Pick类似C1样1（NPC1L1）的表达，并大大降低了ABCG8水平。这些结果首次证明了fucoidan来自。 nodosum attenuated atherosclerosis by regulating RCT-related genes and proteins expression in apoEmice.总而言之，可以探索来自nodosum曲霉的富藻依藻依克甘油，作为预防或治疗高脂血症诱导的动脉粥样硬化的潜在化合物。