亚麻籽补充表现出明显的抗透明胆固醇作用，并改善了主动脉粥样硬化的动脉粥样硬化的变化

H Srinivasa Naik

Background and Aim: Flaxseeds are known to have varying antihypercholesterolemic and antiatherogenic activity due to its lignan塞索拉塞甲醇二葡萄糖苷，α-亚麻酸和omega-3脂肪酸。全谷物饮食亚麻籽的有益效果在高胆固醇饮食（HCD）的Wistar白化病大鼠中对实验进行了实验评估。

材料和方法： 雄性wistar wistar albino大鼠（200 g）分别分为四组12只大鼠。 Group I rats kept as control and given basal rat chew diet, Group II as positive control for induction of hypercholesterolemia and atherosclerosis by addition of 1% cholesterol and 15% saturated edible oil to the 1000 g of standard rat chew diet (HCD), Group III rats fed with whole grain flaxseed powder at 7.5 g/kg of rat/day in the standard rat chew diet and kept as flaxseed control, and Group IV rats supplemented with flaxseed at 7.5 g/kg of rat/day along with HCD and maintained for 90 days.

Results: Group II rats revealed significantly (p<0.05) higher total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol （LDL-C）和非常LDL-C，并且显着（P <0.05）红色高密度脂蛋白胆固醇（HDL-C）的水平，而组织抗氧化剂，例如催化酶，超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPX）（GPX），谷胱甘肽还原酶（GR）和谷胱甘肽S的转移酶（GST）是显着的（p <0.05）心脏和肝组织中硫巴比妥酸反应性物质（TBARS）水平不重要（P <0.05）。亚麻籽补充以及HCD以及HCD显着改善TC，TG，LDL-C和HDL-C的血清水平以及细胞抗氧化酶，例如催化酶，SOD，SOD，GPX，GR，GR，GST，GST，GST，GST，GST，GST，GST，GST，GST，GST，GST，和非显着的TBARS在心脏和Liver II II II II II II II层中。大多数组织病理学引发的主动脉动脉粥样硬化变化和II组肝脏的脂肪变化均未在亚麻籽补充IV组中观察到。但是，有趣的是，内皮细胞的增殖在新的血管通道形成中liver and in between cardiac muscle fibers was observed in Group I and Group IV rats.

Conclusion: The present study established the hypercholesterolemia with initiated atherosclerotic lesion in the aorta but unable to establish the atheromatous plaque in the aorta.亚麻籽补充与HCD一起表现出明显的抗透明胆固醇作用，并改善了主动脉启动动脉粥样硬化的变化。它需要进一步的研究来探讨亚麻籽在实验动物和人类试验中的所有可能的有益作用和血管生成特性。