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Abstract Title:Effects ofMurrill polysaccharides on hyperlipidemic rats by regulation of intestinal微生物群。
摘要来源:
食品Sci Nutr。 2020 Jun; 8(6):2758-2772。 EPUB 2020 APR 19.PMID: 32566193“> 32566193 Xiao Guo, Yu Sheng, Yingna Li, Guangyu Xu, Xiao Han, Liping An, Peige Du
Article Affiliation:Yuxin Li
Abstract:The present research envisaged the effects ofMurrill polysaccharides (ABPs) on blood lipids and its role in regulation of the intestinal microflora in hyperlipidemic rats.通过Deae-Cellulose离子交换柱色谱法获得了酸性多糖分数。 ABP的糖含量为75.1%。与模型组(MG)相比ABP组的血清TC,TG和LDL-C水平降低(<.05或<.01),HDL-C水平显着增加(<.01)。 CYP7A1的表达被上调(<.01),在ABP组大鼠的肝组织中,SREBP-1C的表达显着下调。此外,发现在ABP组中发现肝小叶和肝细胞的脂肪变性可显着缓解。 We believe that ABP can reduce the ratio of Firmicutes/Bacteroidetes and reduce the relative abundance of Firmicutes, Ruminococcaceae_unclassified, and Ruminococcaceae, increasing the relative abundance of Proteobacteria, Clostridium_sensu_stricto, Allobaculum, Peptostreptococcaceae, Clostridiaceae_1, and Erysipelotrichaceae作为调节血脂的靶标。结果展示的ABP可以调节患有高脂血症大鼠的血脂异常。该机制可能是通过调节大鼠高脂饮食引起的肠道菌群的不平衡S,这可能是其对高脂饮食引起的血脂异常干预的重要方法之一。