tourtica dioica L.叶提取物调节自发性高血压大鼠的血压和氧化应激。
摘要来源：
phytomedicine。 2018年7月15日； 46：39-45。 EPUB 2018 APR18。PMID： 30097121“> 30097121 Grujic-Milanovic，Zoran Miloradovic，Djurdjica Jovovic，Milan Ivanov，Danijela Karanovic，Katarina Savikin，Branko Branko Bugarski，Nevena Mihailovic-Stanojevic
Privation Prackance：una-jovana vajiic BACKGROUND: Urtica dioica L. (Stinging nettle) has been used for centuries for the treatment of numerous health issues.
PURPOSE: This study investigates the antioxidant capacity and the most abundant phenolic compounds of Urtica dioica L.叶提取物（UE）及其降压和抗氧化Effects in vivo.
STUDY DESIGN: Spontaneously hypertensive rats were supplemented with 10, 50, and 200 mg/kg/day of UE and 10 mg/kg/day of losartan during 4-week period.
方法： 在本研究中，对UE进行了HPLC分析，并确定了抗氧化能力，超氧化物自由基清除活性和金属螯合能力。血液动力学参数直接在麻醉大鼠中测量。 Also, antioxidant enzyme activity and concentration in erythrocytes were determined, as well as systemic oxidative stress and plasma antioxidant status.
RESULTS: UE showed higher ferric reducing antioxidant power and Trolox equivalent antioxidant capacity than BHT, but lower than维生素C.此外，UE具有良好的金属螯合能力，但超氧化物自由基清除活性。这三个tESTED UE剂量设法降低了收缩压和舒张压以及心脏指数，并通过增加超氧化物歧化酶和过氧化氢酶的活性来改善抗氧化防御，而无需改变酶的浓度。此外，补充UE增加了血浆抗氧化能力和降低的全身氧化应激。