Piperine，黑胡椒的活性物质，减轻没有合酶抑制引起的高血压。
摘要来源：
bratisl lek lik ligk。 2010; 111（8）：426-31。 PMID： 21033621“> 21033621 Cerna, P Babal
Article Affiliation:Department of Pathology, Faculty of Medicine, Comenus University, Bratislava, Slovakia.
Abstract:OBJECTIVES: The presented study is aimed on exploring the effects of black pepper on blood pressure in the rat model of experimental hypertension induced by chronic无综合抑制。
背景： piperine，黑胡椒的化合物，可能会导致正常大鼠血压的显着降低。own to be effective in prevention of L-NAME (N(G)-nitro-L-arginine methyl ester) induced hypertension.
METHODS: Wistar rats were administered clear water (C), L-NAME (40 mg/kg/day, L), piperine (20 mg/kg/day) in用L-Name（LP）或不带（P）的口服玉米油6周。每周测量收缩压。在石蜡中处理胸主动脉的标本，并用苏木精和曙红，杂元磷酸糖质磷酸苏木精（PTAH），甲氧素，甲氧素，抗诱导的无合酶（Inos）和平滑肌细胞（SMCA）染色。微观图片进行数字处理并进行形态计量评估。
结果： l-name增加了血压，主动脉，媒体厚度，弹性蛋白和smca的阳性和ptah阳性的阳性和ptah阳性的相对媒体的血压，媒体厚度，弹性它降低了Inos，弹性蛋白和SMCA的百分比含量。 Piperine decreased the blood pressure rise from the third week of treatment, synthesis of elastin and the percentual and absolute content of PTAH positive myofibrils, however, it did not affect other parameters.
CONCLUSION: Oral administration of piperine is able to partially prevent the increase of blood pressure caused by chronic L-NAME administration.这种作用可能是由于电压依赖性钙通道的阻塞而引起的，并由丝状肌动蛋白拆卸（TAB。1，图2，参考文献35）。