urb。防止高血压并保护慢性一氧化氮缺乏大鼠模型中的心脏。
摘要来源：
前药物。 2021; 12：742562。 EPUB 2021 12月3日。PMID： 34925007 34925007 Kamisah, Mohd Noor Mohd Mustazil, Japar Sidik Fadhlullah Zuhair, Abdul Hamid Juliana, Norliza Muhammad
Article Affiliation:Mohd Khairulanwar Bunaim
Abstract:Hypertension is a major risk factor for cardiovascular disease (CVD), which is the number one cause of global mortality.已经证明，天然产物的潜在用途可以减轻高血压来发挥心脏保护作用。属于植物科（Umbelliferae）。它占领ns a high amount of triterpenoid and flavonoid that have antioxidant properties and are involved in the renin-angiotensin-aldosterone system which is an important hormonal system for blood pressure regulation.This study aimed to investigate the effects ofethanolic extract on blood pressure and heart in a hypertensive rat model, which was induced using oral N(G)-nitro-l-arginine methyl ester (l-NAME).Male Sprague-Dawley大鼠分为五组，并接受不同的治疗方法8周。第1组仅收到去离子水。组2、4和5给出了l-name（40 mg/kg，口服）。第4组和第5组分别接受提取（口服500 mg/kg）和卡托普利（口服5 mg/kg）。第3组仅接受提取（口服500 mg/kg体重）。在第0、4和8周测量收缩压（SBP），而血清一氧化氮（NO）在第0周和第8周进行测量。在尸检时，心脏和主动脉丙二醇（MDA）含量（MDA）含量，心脏血管紧张素转化ENZ ENZ ENZyme (ACE) activity, and serum level of brain natriuretic peptide (BNP) were measured.After 8 weeks, the administrations ofextract and captopril showed significant (<0.05) effects on preventing the elevation of SBP, reducing the serum nitric oxide level, as well as increasing the cardiac and aortic MDA content, cardiac ACE activity, and serum brain natriuretic peptide级别。提取可以防止L-NAME引起的高血压和心脏损伤的发展，并且这些作用与Captopril相当。