大麻种子（大麻sativa L.）粉蛋白水解剂对自发高血压大鼠的高血压的预防和治疗效果。
摘要来源：
eur J nutr。 2014年8月； 53（5）：1237-46。 EPUB 2013 11月29日。PMID： 24292743 He, Sunday Malomo, Rotimi E Aluko
Article Affiliation:Abraham T Girgih
Abstract:PURPOSE: This work determined the ability of hemp seed meal protein hydrolysate (HMH)-containing diets to attenuate elevated blood pressure (hypertension) development in spontaneously高血压大鼠（SHR）。还确定了饮食对SHR中肾素和血管紧张素转化酶（ACE）的血浆水平的影响。使用胃蛋白酶，然后是胰腺素，使用模拟的胃肠道消化水解餐，并将其作为降压肽的来源。 The HMH was substituted for casein at 0.5 and 1.0% levels and fed to young growing rats for 8 weeks (preventive phase) or adult rats for 4 weeks (treatment phase).
RESULTS: Feeding of young growing SHRs with HMH resulted in attenuation of the normal increases in systolic blood pressure (SBP) with an average与仅酪蛋白的大鼠（对照）相比，值约为120 mmHg，最大为158 mm Hg（P <0.05）。在4周期间，喂养成年大鼠（SBP〜145 mmHg），导致SBP的显着降低（P <0.05）至〜119 mmHg，而对照大鼠的150 mmHg则降低了〜119 mmHg。与对照大鼠（0.123 U/mL）相比，HMH喂养大鼠的血浆ACE活性被HMH喂养的大鼠显着抑制（0.047-0.059 U/mL）。血浆肾素水平是lso decreased for HMH-fed rats (0.040-0.054μg/mL) when compared to control rats that were fed only with casein (0.151 μg/mL).
CONCLUSIONS: The results suggest that HMH with strong hypotensive effects in SHRs could be used as a therapeutic预防和治疗高血压的药物。