aspalathin改善了肥胖的糖尿病ob/ob小鼠的高血糖和葡萄糖不耐症。
摘要来源：
eur J Nutr。 2013年9月; 52（6）：1607-19。 EPUB 2012 12月13日。PMID： 23238530“> 23238530 23238530 Miura, Kazumi Yagasaki
Article Affiliation:Myoung Jin Son
Abstract:PURPOSE: Although several researches have demonstrated that rooibos extract has hypoglycemic effect, the role of aspalathin, a main polyphenol in the extract, remains unclear. Our aims were to find specific mechanisms for anti-diabetic action of aspalathin employing a rat skeletal muscle-derived cell line (L6 myocytes) and a rat-derived pancreaticβ-cell line (RIN-5F cells) and to investigate its effect in type 2 diabetic model ob/ob mice.
METHODS: 我们通过研究使用培养的L6肌管对葡萄糖摄取的分子机制进行研究，研究了asspalathin对葡萄糖代谢的影响。我们还测量了aspalathin对RIN-5F细胞中人工晚期糖基化终产物（年龄）产生的反应性氧（ROS）的抗氧化能力。 In vivo, ob/ob mice were fed 0.1 % aspalathin-containing diet for 5 weeks, and the effect of aspalathin on fasting blood glucose level, glucose intolerance, and hepatic gene expression was studied.
RESULTS: Aspalathin dose dependently increased glucose uptake by L6肌管并促进AMP激活的蛋白激酶（AMPK）磷酸化。 Aspalathin在L6成肌细胞和肌管中增强了GLUT4转运至质膜。在RIN-5F细胞中，aspalathin抑制了年龄诱导的ROS上升。在体内，aspalathin显着抑制了空腹血糖水平的增加并改善了葡萄糖不耐症。此外，白杨蛋白降低了与糖生成和脂肪生成有关的肝基因的表达。
结论： atoglycmem效应aspalathin a aspalathin与glut4 transporatoction a plassma emplactoctication cants ampsma empk activation a amp empk aintpactiation ainmpk activation。此外，阿斯帕拉丁降低了与葡萄糖产生和脂肪生成有关的肝酶的基因表达。这些结果强烈表明阿斯帕拉丁具有抗糖尿病潜力。