Click here to read the complete article.
Abstract Title:Thymoquinone Upregulates Catalase Gene Expression and Preserves the Structure of the Renal Cortex of丙基甲酸诱导的甲状腺功能减退大鼠。
摘要来源：
氧化剂MED细胞longev。 2020; 2020：3295831。 EPUB 2020年7月20日。PMID： 32774669“> 32774669艾哈迈德（Ahmed a Mubarak）艾哈迈德（Ahmed a Mubarak）防止肾脏组织损伤和纤维化。这项研究的目的是评估ible protective effect of thymoquinone on the structure of the renal cortex of hypothyroid rats and explore the mechanism behind it.
Methods: An experimental model of hypothyroidism was induced in adult male Wistar rats by administration of propylthiouracil (6 mg/kg/body 重量）。将一种甲状腺功能基型甲基醌以50 mg/kg/体重的剂量治疗，并与未处理的组进行比较。在血清中评估了甲状腺功能和氧化剂/抗氧化剂状态。使用实时聚合酶链反应评估过氧化氢酶基因的表达。在组织学和免疫组织化学上评估肾脏。
结果： 丙基硫硫酸的给药可显着降低，导致静脉疾病和超级氧化酶降低的静脉疾病和超级氧化酶的水平降低。 （<0.001）增加。行政胸喹酮的渗透减轻了对甲状腺激素的影响，并显着提高了抗氧化剂的血清水平。 Thymoquinone significantly (<0.001) upregulated catalase transcription by about 24-fold and could block the hypothyroidism-induced glomerular and tubular injury.
Conclusion: Thymoquinone may have a potential protective effect against hypothyroidism-induced renal injury acting through the氧化应激的衰减和肾氧化酶基因表达的上调。