富含氢的盐水可防止氧气损伤

富含氢的盐水提供了防止高氧肺损伤的保护。

j Surg res。 2011年1月； 165（1）：E43-9。 Epub 2010 10月15日。PMID： 210677781“> 21067781 Liu，Weigang Xu，Hengyi Tao，Xuejun Sun

Qiang sun

背景： 通过其选择性地抗氧化剂，可以证明是一种新型的抗氧化剂。 In this study, we investigated the effects of hydrogen-rich saline on the prevention of acute lung injury induced by hyperoxia (HALI) in rats.

MATERIALS AND METHODS: Physiologic saline, hydrogen-rich saline, or nitrogen-rich saline was administered through intraperitoneal (i.p.)暴露于高氧（10 mL/kg）期间注射分别。

结果： HALI的严重程度通过胸膜积液的体积，湿干的重量比（W/D）和组织学分析评估。用末端脱氧核苷酸转移酶Dutp nick端标记（TUNEL） - 阳性染色确定肺细胞中的凋亡。通过酶联免疫吸附测定法（ELISA）检测到肺组织中促炎性细胞因子白细胞介素IL-1B和TNF-A的含量。富含氢的盐水治疗可通过抑制脂质，DNA氧化和组织水肿来保护HALI。 Moreover, hydrogen-rich saline treatment could inhibit apoptosis and inflammation while no significant reduction was observed in nitrogen-rich saline treated animals.

CONCLUSION: The results of this study demonstrate that hydrogen-rich saline ameliorated hyperoxia-induced acute lung injury by reducing oxidative stress and炎症肺组织中的级联反应。