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Abstract Title:Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.
Abstract资料来源：
ther Adv慢性病。 2020; 11：2040622320922104。 EPUB 2020 6月24日。PMID： 32637058 32637058 Bouyon, Jean-Louis Pépin, Diane Godin-Ribuot, Elise Belaidi
Article Affiliation:Sophie Moulin
Abstract:Background: Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to心肌缺血 - 再灌注后（I/R）后的梗死大小。在心肌损伤的背景下，姜黄素（Curc）是天然色素，已被证明是有益的。在这项研究中，we assessed the effects of Curc on the maladaptive cardiac response to IH, and particularly on IH-induced hypoxia inducible factor-1 (HIF-1) expression, oxidative stress, inflammation, endoplasmic reticulum (ER) stress and apoptosis.
Methods: Swiss/SV129将小鼠暴露于Normoxia或IH（21-5％的FIO，60 s周期，每天8小时，持续21天），并用凝血（100 mg kgday，口服烤肉）或其车辆口服治疗。 Mice were then either euthanised for heart sampling in order to perform biochemical and histological analysis, or subjected to anischemia-reperfusion protocol in order to measure infarct size.
Results: IH increased nuclear HIF-1α expression and superoxide anion (O) production as well as nuclear factor kappa B （NF-KB）P65，葡萄糖调节的蛋白（GRP78）和C/EBP同源蛋白（CHOP）表达。 IH还诱导凋亡和梗塞大小增加I/r。 IH诱导的HIF-1激活，氧化应激，炎症，ER应激和凋亡通过慢性凝血治疗被消除。仅在暴露于IH的小鼠中，凝血还会显着降低梗塞大小。
结论： cURC防止IH诱导的心肌细胞死亡信号。在睡眠呼吸道呼吸道高的患者中，CURC可能被用作持续气道正压的联合疗法。