褪黑激素减轻了缺氧 - 缺血性脑损伤的新生大鼠模型中的大脑和周围组织水肿：与水肿相关蛋白的参与。
摘要来源：
bmc pediatr。 2017年3月28日； 17（1）：90。 EPUB 2017 3月28日。PMID： 28351378> 28351378 Xin Ding, Ying Wang, Xing Han, Ming-Hua Liu, Bin Sun, Xing FengArticle Affiliation:
Li-Xiao Xu
Abstract:BACKGROUND: Previous studies have indicated edema may be involved in the pathophysiology following hypoxic-ischemic脑病（HIE）和褪黑激素可能会针对脑侮辱表现出神经保护。然而，关于涉及褪黑激素在大脑和HIE之后周围组织的保护作用的机制知之甚少。本研究旨在检查梅拉托的影响nin on multiple organs, and the expression of edema related proteins in a neonatal rat model of hypoxic-ischemic brain damage (HIBD).
METHODS: One hundred ninety-two neonatal rats were randomly divided into three subgroups that underwent a sham surgery or HIBD.在HIBD或假伤害后，大鼠分别接受了腹膜内注射的褪黑激素或相等的体积载体。我们通过QPCR和Western blot研究了褪黑激素对脑，肾脏和结肠水肿的影响，包括AQP-4，ZO-1和Occludin，包括AQP-4，ZO-1和Occludin。通过H-E染色和透射电子显微镜评估的HIBD诱导的外围器官。 （2）褪黑激素缓解了HIBD诱导的脑水肿，其特征是增加D脑含水量。 (3) HIBD induced significant changes of edema related proteins, such as AQP-4, ZO-1 and occludin, and these changes were partially reversed by melatonin treatment.
CONCLUSIONS: These findings provide substantial evidence that melatonin treatment has protective effects on the brain and peripheral organs after HIBD和与水肿相关的蛋白AQP4，ZO-1和occludin可能会间接促进褪黑激素保护的机理。