Atractylodes脑力头或Taraxacum Herba提取物可以被视为天然药物，可以预防炎症性肠病复发

kyu-hyun hyun han

Methods: Murine intestinal epithelial IEC-6 cells were pretreated with AM or TH before a脂多糖（LPS）引起的挑战。 Acute colitis was induced with 7 days of dextran sulfate sodium (DSS) in male C57BL/6 mice, and extracts of AM and TH were administered for 2 weeks before DSS administration.

Results: In vitro studies demonstrated that AM or TH treatment reduced LPS-induced COX-2 and tumor坏死因子-αmRNA水平，但血红素加氧酶-1（HO-1）增加。 AM和TH的口服前分泌从DSS诱导的结肠炎中拯救了小鼠，通过通过失活的细胞外信号抑制炎症介质调节激酶和抑制核因子κB和信号传感器和转录3的激活剂，但对磺胺嗪的作用比提取物弱。抗炎活性是通过抑制巨噬细胞和T淋巴细胞浸润而发生的。与没有诱导HO-1的磺氮嗪不同，Th提取物具有显着的HO-1诱导性。

结论： ，因为AM或TH提取物在预防DSS诱导的sulfasazine the empers am或th方面都远远超出了sulfasazine，sulfasazine the eftrent sulfasazine，复发。