Punicalagin对流感病毒的体外抗病毒评估

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Anantiviral evaluation of punicalagin toward influenza A virus.

avicenna j phytomed。 2024; 14（4）：496-504。 PMID： 38952775“> 38952775 Nikoo，Mohammad-Taghi Moradi，Alijan Tabarraei

fatemeh javadi-farsani

obvocey>客观： 造成了严重的造成死亡，并可能死亡，并在某些情况下死亡。近年来，人们对开发和使用新的抗病毒化合物来克服某些流感病毒菌株的耐药性并治疗临床意义。这项研究旨在调查AntiviPunicalagin及其相关机制对流感（H1N1）病毒的影响。

材料和方法： 使用Madin-darby canine fimney（Madin-darby canine fircai）（Madin-darby canine firuce a Tailte aflutialagin） RICO/8/34（H1N1）（PR8）使用血凝素分析（HA）和50％组织培养感染剂量（TCID）。 Then, the inhibition of haemagglutination, virucidal activity, inhibitory effect at different times, replication of viral RNA and expression of viral genes were investigated.

RESULTS: Punicalagin could inhibit influenza virus infection with 50% inhibitory concentration (IC) of 3.98μg/ml，选择性指数（SI）值为6.1。 Punicalagin降低了病毒滴度，对病毒血凝性有抑制作用（P <0.05）。 Punicalagin还抑制了病毒吸附。病毒RNA复制和病毒mRNA（NS1和HA）的结果表达ion after treatment with punicalagin showed significant suppression of viral mRNA expression but no effect on replication of viral RNA.

CONCLUSION: The results of the present study indicated that punicalagin was effective against influenza infection most probably via inhibition of haemagglutination activity and virus绑定。