人参皂素介导的抗炎作用的新机制通过靶向规范炎性体信号通路。
摘要来源:
j et nnopharmacol。 2021 Jun 3; 278:114292。 EPUB 2021 6月3日。PMID: 34089812 Young-Su yi 民族药理学相关性: 人参是亚洲国家的民族药物草药植物,尤其是在韩国,中国和日本。人参皂苷,包括人参皂苷,是人参的主要活性成分,已被证明对各种人类疾病具有许多药理作用。
材料和方法: <> <>使用搜索文献探索了文献,例如使用诸如“偶然的saponins and Inrovers”和“ Indersent and Inrover”探索。 inflammasomes"in several resources, such as PubMed, Google Scholar, and Scopus databases.
RESULTS: Various ginseng saponins of Panax ginseng, Panax japonicas, and Panax quinquefolius alleviated inflammatory responses and diseases by inhibiting the nucleotide-binding寡聚结构域样受体(NLR)P3(NLRP3)炎症体激活。另外,Panax Ginseng的RG1人参SPONIN通过抑制NLRP1炎症体激活来缓解神经炎症和疾病。最后,Panax人参ameliorated sepsis by inhibiting absent in melanoma 2 (AIM2) inflammasome activation.
CONCLUSION: The studies discussed in this review provide insight into the new paradigm of the ginseng saponins as the promising anti-inflammatory agents that could be ethnopharmacologically used to prevent and通过靶向炎症来治疗炎症和炎症引起的疾病。