低水平的红色LED光抑制了在体外模型中由不饱和脂肪酸诱导的过度分泌和炎症模仿痤疮

BACKGROUND AND OBJECTIVE: Acne vulgaris is a chronic inflammatory disease of the pilosebaceous units (PSU), associated with increased sebum production, abnormal follicular角质化（高脂化），丙酸杆菌（P.痤疮）的卵泡过度生长，并增加了炎症介质释放。光治疗吸引了医疗利益，作为痤疮的安全替代疗法。高剂量的蓝色和红光疗法> 10 J/CM（2）表现出对炎症性痤疮病变的明显影响。但是，很少有研究研究较低剂量的光的影响。 The aim of this study is to investigate the biological effects of lower doses of red light at 0.2-1.2 J/cm(2) for acne using an in vitro model previously developed to mimic the inflammation and hyperkeratinization observed clinically in acne.

MATERIALS AND METHODS: Human epidermal equivalents were topically exposed到不饱和脂肪酸，油酸（OA），然后进行红色光发射二极管（LED）光处理（光plus-OA处理）。 Endpoints evaluated included the proinflammatory cytokine IL-1α, epidermal barrier integrity, as measured by transepithelial electrical resistance (TEER), and stratum corneum (SC) thickness to monitor hyperkeratinization.

RESULTS: OA-induced IL-1α release was显着（p <0.05）在0.2、0.5和1.2 j/cm（2）处红色LED光线后，从266±11 pg/ml的无光plus-oa处理（无光对照）到216±9、231±8和212±7 pg/ml。组织学检查表明，在0.5和1.1 J/cm（2）红光加上OA处理后，无光 - Plus-OA治疗的总表皮的43％从表皮的43％和38％的总表皮降低到37％和38％（p <0.05）。 Moreover, 1.1 J/cm(2) red-light-plus-OA treatment improved OA-induced TEER changes from 29% of baseline for no-light-plus-OA treatment, to 36% of baseline.

CONCLUSION: Low level red LED light therapy could provide beneficial effects of anti-inflammation, normalizing毛s骨超高性化，并改善痤疮粉刺的障碍。激光外科手术。 Med。©2017 Wiley Wendericals，Inc。