Paeonia乳酸根提取物对cAMP-磷酸二酯酶活性和相关抗炎作用的影响。
摘要来源:
j ethnopharmacol。 2011年9月1日; 137(1):914-20。 EPUB 2011年7月18日。PMID: 21782011“> 21782011 Xu,Xiang Mu,Wu Chen
文章隶属关系:daixun jiang
摘要:
背景: paeon> 方法: PDE活性是通过用HPLC检查的营地变化计算的,用细胞色素C的方法检测到中性粒细胞的呼吸道爆发,释放弹性酶的弹性酶的释放是用底物减少来指示的,大鼠关节炎的模型是由完全弗雷德斯辅助剂量的ba caciTy canciti cancity dression dressian dressi caid dequins and ba引起的,并且是由小鼠胶合剂的化学量引起的。 identified by HPLC, mass spectroscopy and NMR spectrum. RESULTS: Baishao extract had significant inhibition on cAMP-PDE activity (p<0.01), had dose dependent restraint on neutrophils respiratory burst (p<0.001), had inhibition at low concentration and promotion at高浓度的弹性酶释放(p <0.05),并且对动物模型的局部炎症有明显的约束(p <0.01)。lfonate, albiflorin, paeoniflorin and benzoic acid), among which gallic acid had the largest inhibition on cAMP-PDE activity. CONCLUSION: The anti-inflammatory effects of baishao may be mediated, at least in part, through its gallic acid content, and this effect may be regulated in部分通过抑制营地。