单击此处阅读完整的文章。物种/NOD样受体热蛋白结构域相关蛋白3/caspase-1信号传导途径。
摘要来源：
免疫炎症。 2024 Jun; 12（6）：E1309。 PMID： 38860765“> 38860765 Yandong Chen, Yuanhong Zhou, Xiaolin Zhou, Qiang Liu
Article Affiliation:Xiaoli Huang
Abstract:BACKGROUND: Astragaloside IV (AS-IV) is the most active monomer in the traditional Chinese herbal medicine Radix Astragali, which具有广泛的抗病毒，抗炎和抗纤维化药理作用，并显示了Protective effects in acute lung injury.
METHODS: This study utilized the immunofluorescence, flow cytometry, enzyme-linked immunosorbent assay, quantitative reverse transcription-polymerase chain reaction, western blot, and hematoxylin and eosin staining methods to investigate the mechanism of AS-IV in reducing viral pneumonia caused by influenza A virus in A549 cells and BALB/c mice.
RESULTS: The results showed that AS-IV suppressed reactive oxygen species production in influenza virus-infected A549 cells in a dose-dependent manner, and随后，抑制了核苷酸结合寡聚结构域的激活，类似于受体的受体热蛋白结构域相关蛋白3炎症体和caspase-1，降低了白介素（IL）-1β和IL-18分泌。在感染聚（I：C）的BALB/C小鼠中，AS-IV的口服给药可显着降低聚（I：C）诱导的急性PNEUMONIA和肺病理损伤。
结论： as-iv减轻了体外和肺部损害和肺部损害，vivo in vivo in vivo