摘要来源: 药物认知Res。 2012年7月; 4(3):134-7。 PMID: 22923950“ Aadesh Upadhyay, Anurag Pandey, Sanjeev Karmakar, Lokendra Singh Pronobesh Chattopadhyay BACKGROUND: Vitex negundo L. (Verbenaceae) is a hardy plant widely distributed in the Indian次大陆并用于治疗传统和民间医学的各种健康障碍,其中一些已通过实验验证。在present study, we aimed to investigate the anti-inflammatory effects of V. negundo in carrageenan-induced paw edema in rats, and to investigate the probable mechanism of anti-inflammatory action. MATERIALS AND METHODS: Paw edema was produced by injecting 1% solution of carrageenan, and the paw在面包片注射长达5小时之前和之后测量体积。 V. Negundo叶油是使用Clevenger设备提取的,并通过传播到Wistar大鼠的途径进行给药,并通过比较一个基于复合气溶胶的配方与1 mg Dicolofinac dicolofinac diclofinac diethylamine bp和7 mg甲基甲基甲基甲基甲基甲基甲基化的甲基甲基甲基化的甲基甲基化的甲基甲基化的甲基甲基化剂,并使用多个基于气溶胶的配方观察到炎症的抑制百分比。安慰剂组。退出血液后,分离血清,环氧合酶(COX)-1和COX-2抑制活性通过USIN测量酶免疫测定法(EIA)方法G A COX抑制剂筛选试剂盒。 结果和讨论: v。与安慰剂组(Popaffin Oil)和1 mg diclofinac二甲基胺BP和7 mg甲基水杨酸酯IP相比,Negundo Leaf Oil显着降低了Carrageenan诱导的PAW水肿,与V. v. negundo Leaf Chore Greats Group相比,PAW抑制作用的最大抑制作用。 Also in the present study V. negundo leaf oil showed significantly (P<0.05) inhibits COX-1 pathways rather than COX-2 pathways as compared to the V. negundo leaf oil treated group. CONCLUSION: It is suggested that the V. negundo leaf oil is a potent anti-inflammatory agent and acts via抑制COX-2没有太多干扰COX-1途径。