摘要来源： j Justramm res。 2019; 12：231-239。 EPUB 2019年8月29日。PMID： 31695470 Zambrano, Yong Du, Maria Bondesson, Chandra Mohan Thao Nguyen Background: Polyphenol catechins from green tea, particularly (-)-epigallocatechin-3-gallate (EGCG), exhibits numerous beneficial健康效应，尽管该机制尚不清楚。 方法： 在这项研究中，机制ism of EGCG-mediated healing in an experimentally injured zebrafish model was examined at the cellular and molecular level using confocal microscopy and gene expression analysis. Results: The mechanisms of action of EGCG were shown to involve: (1) reducing neutrophil response (accumulation,行进速度和距离）和（2）下调IL-1β，TNFα和相关信号通路的表达。通过动态延时跟踪研究确定，受伤后具有高迁移速度的中性粒细胞的局部积累（n = 33个细胞，v =0.020μm/s，d =37.8μm），用EGCG剂量为300μm（n = 22个细胞，v =0.013μm/s，d = 39.5m/s，d = 3.5mm/s d = 3.5mm/s，d = 3.5m/s，d = 3.5 = 3.5 = 39.5m/s，d = 3.5 = 3.5 = 3.5 = 39.5 = 3.5 = 3.5 = 3.5 = 3.5 = 3.5 = 3.5.5 = 39.5 = 3.5.5.5 = 3.5.5 = 39.5（细胞，v =0.008μm/s，d =9.53μm）。逆转录聚合酶链反应研究表明，EGCG处理后，IL-1β，TNFα和相关信号传导途径中的几个签名基因被下调。 结论： 斑马鱼模型的便利性，透明度和简单性促进了实时跟踪荧光中性粒细胞，以监测炎症，以监测炎症并评估治疗剂的影响。