单击此处阅读完整的文章。 摘要标题:
摘要标题:
curmin-inmer facrumation myant facrammin anti antirhimin anti antirhimin anti antirhimin antimin antimin anti anti and rammin antimin antimin antimin antimin antirh and iolarmin antirh Nanoemulgel。
摘要来源:
聚合物(Basel)。 2021年2月14日; 13(4)。 EPUB 2021 2月14日。PMID: 33672981 33672981 Shehata,Maged E Mohamed,Nancy S Younis,Heba S Elsewedy
文章隶属关系:wafaa e soliman
摘要:
背景: backgromnal: curcumin(curcumin(curcumin)(curcumin(curcumin),包括各种有益的物质,包括抗癌和抗炎活动。然而,低水溶性和随后的差生物利用度极大地限制了其有效性。此外,没药油作为一种最近已经证明了治疗炎症性疾病的精油。 The objective of the current investigation is to enhance Cur efficacy via developing Cur nanoemulgel, which helps to improve its solubility and permeability, for transdermal delivery.
METHODS: The formulated preparations (Cur gel, emulgel and nanoemulgel) were evaluated for their physical appearance, spreadability,粘度,粒径,体外释放和离体药物渗透研究。使用Carrageenan诱导的大鼠后爪水肿方法估算体内抗炎活性。
结果: 配方式的cur-载载量均具有良好的物理特征,表现出了良好的跨跨跨跨跨跨跨跨跨跨跨跨跨跨型的物理特征。 12小时后,从凝胶,emulgel和纳米素中释放CUR的释放分别为72.17±3.76,51.93±3.81和62.0±3.9%。皮肤渗透将CUR定为纳米果素时,CUR显着改善(<0.05),因为它显示出最佳的稳态透皮通量(SSTF)值(108.6±3.8 µg/cm·H),最高增强率(ER)(ER)(ER)(7.1±0.2)。 In vivo anti-inflammatory studies proved that Cur-loaded nanoemulgel displayed the lowest percent of swelling (26.6% after 12 h).
CONCLUSIONS: The obtained data confirmed the potential of the nanoemulgel dosage form and established the synergism of myrrh oil and Cur作为晚期抗炎药。