星形胶质苷IV通过小鼠的PPARγ信号激活与AOM/DSS诱导的结肠炎相关的肿瘤发生。
摘要来源：
phytomedicine。 2023年12月; 121：155116。 EPUB 2023 9月23日。PMID： 37776619“> 37776619 Pengcheng Li，Meiling Zhang，Xueqian Xie，Xuting Xie，Yunliang Chen，Qing Wang，Lian Zhou，lian luo
文章隶属关系：junjie liang
摘要：
METHODS: To investigate the effect of astragaloside IV against CAC and the underlying机理，C57小鼠用（20、40、80 mg/kg）星形胶质胶IV处理，而CAC则通过腹膜内注射10 mg/kg偶氮甲烷（AOM）和2％葡萄糖硫酸盐硫酸盐硫酸盐含量（DSS）诱导。 We re-verified the activating effects of astragaloside IV on PPARγsignaling in IEC-6 cells, which were reversed by GW9662 (the PPARγinhibitor).
RESULTS: Our results showed that astragaloside IV significantly improved AOM/DSS-induced CAC mice通过抑制结肠缩短，防止肠粘膜损伤，减少肿瘤的数量和Ki67蛋白的表达。此外，黄色盐IV可以激活PPARγ信号，这不仅促进了NRF2和HO-1的表达，还恢复了SOD，CAT和GSH的水平，而且还抑制了iNOS的表达，并降低了肠内和IEC-6细胞中NO的产生。 GW9662在体外可以逆转这种效果。 Astragaloside IV thus decreased the level of ROS and NO in the intestinal tract of mice, as well as reduced the damage of DNA, and therefore inhibited the occurrence of CAC.
CONCLUSION: Astragaloside IV can activate PPARγsignaling in intestinal epithelial cells and reduces肠炎引起的DNA损伤，从而抑制结肠肿瘤发生。这项研究的新颖性是使用PPARγAS抑制DNA损伤以防止CAC发生。