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Abstract Title:Anethole ameliorates inflammation induced by monosodium urate in an acute gouty arthritis model via inhibiting TLRS/MYD88途径。
摘要来源：
过敏剂免疫病（MADR）。 2022; 50（6）：107-114。 EPUB 2022 11月1日。PMID： 36335453 36335453 Xueming Yao, Zhengqi Liu, Xiaodong Zhang
Article Affiliation:Yuepeng Cao
Abstract:OBJECTIVE: To assess the effects of anethole on monosodium urate (MSU)-induced inflammatory response, investigate its role in acute gouty arthritis （AGA），并验证其分子机制。
方法： 苏木精和曙红染色进行了对踝关节肿胀程度的测定和时间依赖性检测，以评估苯甲苯对MSU诱导的AGA小鼠关节损伤的影响。 Enzyme-linked-immunosorbent serologic assay was performed to demonstrate the production levels of inflammatory factors (interleukin 1β[IL-1β], interleukin 6 [IL-6], interleukin 8 [IL-8], tumor necrosis factorα[TNF-α], and monocyte chemo-attractant protein-1 [MCP-1]) in MSU-induced AGA老鼠。使用蛋白质印迹测定法来确认苯甲苯对含寡聚结构域的受体家族pyrin结构域3（NLRP3）炎症体活动的影响以及在MSU诱导的AGA诱导的AGA小鼠中的TOLL-MYELOID分化因子88（MYD88）途径的激活类似TOLLS的受体（TLRS） - 乳突分化因子88（MyD88）途径。 class =“ sub_abstract_label”>结果： 我们观察到MSU诱导的AGA小鼠发生了显着的关节损伤。苯甲烷可以减轻MSU诱导的AGA小鼠中滑膜的病理损伤，并抑制脚踝SWElling。此外，我们观察到，苯甲甲烷可以抑制MSU诱导的MSU诱导的AGA小鼠的炎症反应和炎症体激活。此外，我们发现苯甲烷能够抑制MSU诱导的AGA小鼠中TLRS/MYD88途径的激活。 Our findings further confirmed that anethole contributed to the inhibitory effects on progression in MSU-induced AGA mice.
CONCLUSION: It confirmed that anethole ameliorated the MSU-induced inflammatory response in AGA micevia inhibiting TLRs-MyD88途径。